Plain-English translation of NCT06906939 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This study is testing repetitive transcranial magnetic stimulation (rTMS)—a non-invasive procedure that uses magnetic pulses to stimulate parts of your brain—to see if it can help relieve both knee arthritis pain and depression symptoms. Researchers believe that because pain and depression are closely connected in the brain, treating both at once might work better than treating just one. You would receive this brain stimulation twice a week while also participating in Tai Chi classes.
Many people with knee arthritis also struggle with depression, and the two conditions seem to make each other worse. While this treatment has shown promise for other types of chronic pain, researchers want to test whether targeting two specific brain regions related to both pain and depression together will be more effective than previous approaches.
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You would visit the study site twice per week for brain stimulation sessions (rTMS treatment) over 3 months, with the intensity gradually increased over your first few sessions. You would also attend Tai Chi classes twice per week as part of the program. Some participants will receive active brain stimulation while others receive a sham (placebo) version, without knowing which they received. After the 3-month treatment period, you would return for follow-up visits at 6 months and 12 months to see how you're doing.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States