Plain-English translation of NCT06914284 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to find reliable early warning signs of cognitive decline (memory and thinking problems) in older adults with bipolar disorder. This study will use three main tools to do this: a wristband that tracks your daily movement patterns, an MRI brain scan to look at brain structure and function, and cognitive tests that measure memory and thinking skills. By comparing these measurements in people with bipolar disorder to healthy volunteers of the same age, researchers hope to identify which older adults are at highest risk for developing dementia.
Older adults with bipolar disorder sometimes develop memory problems and cognitive decline, but doctors don't yet have reliable ways to predict who will be affected. This study aims to find objective biological markers—measurable signs in brain imaging and movement patterns—that could help identify people at risk before serious memory loss occurs.
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You will visit the research center on day 1, where you'll receive a wristband device to wear for 5 days that tracks your movements. During this time, you'll complete three cognitive tests—including memory tasks and a storytelling exercise where you describe memories with different emotions. On day 5, you'll return to have an MRI brain scan (about 45 minutes long) that takes detailed pictures of your brain structure and function. The entire study involves one in-person visit lasting a few hours on each of days 1 and 5, plus wearing the wristband continuously in between.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
France