Plain-English translation of NCT06914466 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is testing whether adjusting deep brain stimulation settings can help reduce sleep problems in people with Parkinson's disease who already have a deep brain stimulation device implanted. Researchers will record how your brain responds to different stimulation settings and use that information to develop a smarter, personalized approach to treatment. The goal is to understand how this technology can work better for you and eventually create devices that automatically adjust to your changing needs.
Many people with Parkinson's disease struggle with sleep problems like insomnia, nightmares, and restless nights, which can make their other symptoms worse and reduce quality of life. Currently, doctors use standard settings for deep brain stimulation, but this study aims to learn how personalized, adaptive settings could provide better sleep improvement.
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You will visit the hospital for clinical assessments and sleep studies at baseline (before any changes), then at 1, 3, 6, and 12 months after your deep brain stimulation device is adjusted. During overnight stays, researchers will record your sleep using special monitors and measure your brain activity through your existing device. After researchers identify the best stimulation settings for you using computer analysis, you will try the personalized adaptive version of the treatment for one month, then switch back to standard treatment for another month—with sleep studies and symptom assessments after each phase to compare how well each works.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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