Plain-English translation of NCT06919939 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether two medications — and — work better together to fight large B-cell lymphoma that has returned or stopped responding to earlier treatments. Both medications are designed to help your immune system recognize and attack lymphoma cells. Researchers want to see if combining them is safe and effective for reducing or eliminating the cancer.
People with large B-cell lymphoma that comes back or doesn't respond to standard treatment often have very few good options left. This trial explores whether this new combination approach might offer hope to patients in that difficult situation.
You likely qualify if…
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You would receive the two medications together for the first 3 months (4 cycles of 21 days each), then continue with one of the medications alone for another 8 months (8 cycles of 28 days each), for a total of about 12 months of active treatment. You would need to visit the trial site regularly for infusions, blood tests, and scans to monitor how well the treatment is working. Your total involvement in the study would be approximately 3 years, including follow-up visits after treatment ends.
AI-generated summary from trial data · Jun 15, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
University of Miami
Collaborators
ADC Therapeutics S.A., Genmab
Enrollment target
~26 participants
Started
January 2026
Primary completion
January 2031
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Juan Alderuccio, MD
University of Miami
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.