Plain-English translation of NCT06922318 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether , a new medication, works better when combined with testosterone injections first, and then later with a different medication called . The study is for men whose advanced prostate cancer has stopped responding to standard hormone-blocking drugs. Researchers hope this two-step approach will delay cancer progression longer than treatments used in the past.
Many men with advanced prostate cancer eventually develop resistance to current standard treatments, meaning their cancer starts growing again despite medication. This trial is designed to find a new treatment strategy that can work when those standard options no longer help.
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You would start by taking a daily pill () and receiving a testosterone injection once per month, continuing until your scans show the cancer is progressing. At that point, you would switch to taking two different daily medications ( at a higher dose plus ) to see if this second combination works better. You will continue on your regular hormone therapy shots throughout the trial, and you'll have regular scans and blood tests to monitor how well the treatment is working.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States