Plain-English translation of NCT06923345 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination treatment approach for advanced rectal cancer that hasn't been treated before. The three-part treatment includes long-course radiation therapy, chemotherapy (CAPOX), and a PD-1 inhibitor (an immune-boosting medication). The study wants to see if this combination helps more patients achieve a complete response to treatment and improves their long-term outcomes.
Advanced rectal cancer is difficult to treat, and doctors are looking for better ways to shrink tumors before surgery and improve survival. This medication works by helping the immune system fight cancer, and combining it with traditional radiation and chemotherapy might be more effective than either treatment alone.
You likely qualify if…
You likely don't qualify if…
You will receive long-course radiation therapy (combined with chemotherapy and immune therapy) for several weeks, followed by additional chemotherapy and immune therapy cycles. The study compares two slightly different radiation approaches to see which works better. After completing the medication phases, you may have surgery to remove the tumor, or your doctor may recommend watching and waiting if the cancer has completely disappeared. Throughout the trial, you'll have regular check-ups, imaging tests, and blood work to monitor your progress and safety.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
China