Plain-English translation of NCT06928246 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This pilot study is testing whether Onabotulinum Toxin Type A (Botox) injections into eczema patches can help reduce inflammation and improve symptoms. Researchers believe that nerves in the skin release chemicals that keep eczema lesions active, and this medication may block those signals. By studying skin samples before and after treatment, scientists hope to understand new ways to treat eczema in the future.
Eczema is a chronic, uncomfortable skin condition that affects millions of people and significantly impacts quality of life. Early evidence suggests that the medication might help eczema by interrupting communication between nerves and immune cells in the skin, but this approach has not been thoroughly studied in eczema patients.
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You will receive injections of the medication into two or three of your eczema patches, depending on which phase of the study you join. Researchers will take small skin samples (biopsies) before and after treatment to examine how your skin's nerves and immune cells respond. You will be monitored to see whether your eczema improves and to track any side effects.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Daniel Kaplan
Collaborators
Almirall, S.A.
Enrollment target
~8 participants
Started
July 2025
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
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Central contact
Charity Ruhl, LPN
University of Pittsburgh
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