Testing a new diabetes and heart disease medication

Plain-English translation of NCT06932874 on ClinicalTrials.gov ↗ · Source last updated April 2025 · Translation generated July 2026 · How we translate trials

Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.

What is this trial?

This trial is testing a new sustained-release form of metformin hydrochloride, a common diabetes medication, in people who have both type 2 diabetes and heart disease. Researchers want to compare this new version to the standard metformin pill to see if it controls blood sugar just as well but causes fewer stomach side effects. About 356 people will participate over 6 months.

Many people with diabetes and heart disease struggle with stomach upset from their diabetes medications, which can make them stop taking the pills they need. This trial hopes to see if the new formulation of the medication causes fewer digestive problems while still keeping blood sugar under control.

Do you qualify?

You likely qualify if…

you are between 30 and 75 years old
you have been diagnosed with type 2 diabetes with blood sugar levels that are not yet at goal despite taking diabetes medications for at least 12 weeks
you have been diagnosed with coronary heart disease by angiography and are receiving standard heart disease treatment
you have either newly diagnosed diabetes (managed only with diet and exercise) or existing diabetes that isn't controlled well enough yet
your body mass index is between 18.5 and 35

You likely don't qualify if…

you have taken metformin or GLP-1 receptor agonist medications within the past 4 weeks
you have had a recent heart attack or severe heart failure within the past 4 weeks
you have a history of severe stomach problems like gastric bleeding, peptic ulcers, or severe acid reflux in the past 12 weeks
you have serious liver or kidney disease, or your kidney function is very low
you are pregnant, planning to become pregnant, or breastfeeding

What participation looks like

You will take the assigned medication (either the new form or standard metformin) combined with your other diabetes medications for 24 weeks. You'll have clinic visits at the start, 12 weeks, and 24 weeks for blood tests and check-ups, plus phone calls at 4, 8, 16, and 20 weeks to ask about how you're doing and any stomach problems. The main things researchers will measure are your blood sugar control and how often you experience side effects.

AI-generated summary from trial data · Jul 1, 2026 · Not medical advice

Trial locations(1 site)

China

Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, Beijing Municipality