Understanding genetic risk factors for ovarian cancer in Italian women

The PROVE Study is investigating how genetic factors — particularly something called a polygenic risk score, which looks at patterns in your DNA — can help predict who is at higher risk for ovarian cancer and how patients might respond to different treatments. Researchers are comparing women who have been diagnosed with epithelial ovarian cancer to women without a history of the disease, collecting blood samples and detailed health and lifestyle information from both groups.

Ovarian cancer is often diagnosed late because there are no reliable early warning signs. By understanding the genetic risk factors that make some women more susceptible to this disease, doctors hope to identify high-risk women earlier and personalize treatment decisions based on each woman's genetic profile.