Recruiting

Testing a new heart medicine combined with an existing heart drug

Plain-English translation of NCT06935370 on ClinicalTrials.gov ↗ · Source last updated October 2026 · Translation generated September 2026 · How we translate trials

What is this trial?

This trial is testing whether a new drug called , combined with a medicine you may already be taking (), can help people with heart failure feel better and stay healthier. The study compares this combination to a placebo (a pill with no medicine) plus to see which works better. You'll have an equal chance of receiving either treatment.

Heart failure with a weakened left pumping chamber is serious, and doctors are looking for new ways to help patients manage their symptoms and avoid hospital stays. This medication may offer an additional tool to protect the heart and improve quality of life.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with chronic heart failure for at least 3 months
your heart's left pumping chamber is weakened (ejection fraction less than 40%)
you have heart failure symptoms that cause some limitation of physical activity (New York Heart Association class II to IV)
you have elevated NT-proBNP levels, a blood marker that shows heart stress
you are willing to use reliable birth control if you could become pregnant

You likely don't qualify if…

you are currently taking certain heart medicines, like mineralocorticoid receptor antagonists or potassium-sparing diuretics, that cannot be paused for the study
you have had recent heart failure hospitalization requiring IV medications or mechanical heart support within 24 hours of enrollment
you are taking multiple ACE inhibitors, ARBs, or similar blood pressure medicines at the same time
you require systemic steroid replacement therapy or other aldosterone-blocking drugs that would interfere with the study medication

What participation looks like

You will take one tablet by mouth every day for about 6 months to 3.5 years—either the study medication plus or a placebo plus . You'll continue your regular heart failure medicines during the study. You'll visit the study clinic regularly (the exact number depends on how long you stay), and study staff may also call you for some check-ins. During these visits and calls, doctors will monitor your health, ask how you're feeling, and watch for any signs that your heart failure is getting worse or improving.

Testing a new heart medicine combined with an existing heart drug

What is this trial?

Do you qualify?

What participation looks like

Trial locations(594 sites)