Plain-English translation of NCT06936163 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Hereditary spastic paraplegia is a genetic condition that damages nerve pathways in the spine, often causing the feet to curl inward or become contracted in ways that make walking painful and difficult. This study is testing whether surgery to correct these foot problems can improve how well people walk and their overall quality of life. Researchers will follow patients over two years to understand which patients benefit most from surgery and when it works best.
Many people with hereditary spastic paraplegia develop severe foot deformities that don't respond to physical therapy, stretching, or medications alone. This trial exists to find out whether surgical correction can truly help restore walking ability and reduce pain, and to figure out the best age or stage of disease to perform surgery.
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If you join this study, you would receive surgical correction of your foot deformity at Shanghai 6th People's Hospital. After surgery, you would attend regular follow-up visits over a two-year period where doctors would assess your walking ability, measure your foot position, evaluate your pain levels, and test your quality of life. The study involves physical examinations and functional tests to see how much the surgery has helped you walk and function in daily activities.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
China
Sponsor
Shanghai 6th People's Hospital
Enrollment target
~100 participants
Started
March 2025
Primary completion
March 2027
Age range
10 Years – 45 Years
Last updated on clinicaltrials.gov in April 2025.
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Central contact
Li Cao, phD
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.