Testing a wound-healing matrix for hard-to-heal wounds

Plain-English translation of NCT06939673 on ClinicalTrials.gov ↗ ·

What is this trial?

This trial is testing a treatment called Miro3D Wound Matrix, which is made from processed pig liver tissue and shaped like a three-dimensional scaffold. Researchers want to see if applying this matrix directly to difficult-to-heal wounds—such as diabetic foot ulcers, pressure ulcers, and surgical wounds—helps them heal better when used together with standard wound care. The study will follow 20 adults for 12 weeks to measure how much the wound shrinks and whether new healthy tissue forms.

Many chronic wounds, especially those in people with diabetes or limited blood flow, are very hard to treat and heal slowly or not at all. This treatment aims to give the wound a biological scaffold that supports the body's natural healing process and works better than standard care alone.

Do you qualify?

You likely qualify if…

you are 18 years or older and able to give informed consent
you have an open wound or ulcer that is between 1 and 40 square centimeters in size
you are willing and able to follow offloading or compression instructions and keep your wound clean at home
you have a stable living situation where you can receive regular wound care and attend weekly clinic visits
you are willing to have your wound photographed for the study

You likely don't qualify if…

you have an active bone infection (osteomyelitis) that is not being treated
you are known to be allergic to pig products or porcine materials
you have cancer at or near the wound site, or you are currently undergoing chemotherapy
you are on dialysis or have worsening loss of blood flow (ischemia) or dead tissue (gangrene) in the wound area
you have used an investigational drug or therapy in the 30 days before screening

What participation looks like

You will visit the clinic weekly for 12 weeks. During the first 4 weeks, the matrix will be applied to your clean wound once per week. After that, if your wound hasn't fully closed, the matrix will be reapplied every 2 weeks through week 12 or until healing is complete. At each visit, the clinic team will measure your wound size, take photographs, and assess how much healthy tissue is forming. You will also continue all standard wound care—including cleaning, dressing changes, and any compression or offloading needed—and must follow these instructions at home between visits.

Testing a wound-healing matrix for hard-to-heal wounds

What is this trial?

Do you qualify?

What participation looks like

Trial locations(2 sites)