Plain-English translation of NCT06940609 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a treatment called accelerated iTBS (intermittent theta burst stimulation), which uses magnetic pulses to stimulate a specific part of the brain involved in mood and thinking. The goal is to see if this non-invasive brain stimulation can improve the neurological and psychiatric symptoms that some people experience after COVID-19 infection, such as brain fog, difficulty concentrating, mood changes, and anxiety. Half of participants will receive active treatment while the other half receives a sham (fake) treatment, so researchers can fairly measure whether the real treatment works.
Many people with Long COVID experience lasting cognitive and mood problems that significantly affect their daily functioning and quality of life. Currently, there are no proven, effective treatments for these symptoms, so researchers are testing whether this type of brain stimulation might help reduce them.
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You would receive 50 total sessions of magnetic brain stimulation delivered over 10 days (5 sessions per day), with researchers using brain imaging to target the treatment to a specific region involved in mood and thinking. The first 25 sessions would be blinded, meaning you won't know if you're receiving real or sham treatment; the remaining 25 sessions would be open-label (you'll know you're getting the active treatment). Throughout the study, you'll complete assessments of your cognitive symptoms, mood, anxiety, and quality of life, and undergo brain imaging scans to help researchers understand how the treatment works.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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