Plain-English translation of NCT06941389 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
The WeDecide study is comparing two different treatment approaches for children with sickle cell disease: stem cell transplant from a matched family donor and non-transplant medications that help manage the disease. Researchers will follow about 480 children over three years to understand how each treatment affects their quality of life, brain function, and long-term health. This is the first large study to carefully compare these two options side by side.
Right now, families and doctors don't have clear, large-scale research showing which treatment option works better for children with sickle cell disease in the long run. This study aims to fill that gap so families can make informed decisions about whether stem cell transplant or other medications are the best choice for their child.
You likely qualify if…
You likely don't qualify if…
If you're in the transplant group, you'll have assessments before your transplant and then at several points afterward. If you're in the medication group, you'll start with an initial visit and then return for check-ups once a year for three years. At each visit, researchers will ask about your health, quality of life, and thinking ability, and they'll review your medical records to track how you're doing and what healthcare you've used.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States