One-day radiation treatment for large liver cancer tumors

Plain-English translation of NCT06944483 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

What is this trial?

This trial is testing a faster way to deliver a treatment called radioembolization (using SIR-Spheres) for people with large liver cancer tumors. Radioembolization works by injecting tiny radioactive beads directly into the blood vessels feeding the tumor to shrink it. The study is exploring whether doctors can safely complete all the planning and treatment steps in a single day for carefully selected patients, rather than spreading them across multiple days.

Currently, radioembolization usually requires patients to return to the hospital on separate days for imaging, planning, and treatment. This new approach aims to streamline the process and get treatment started faster for eligible patients, while also reducing waste of the radioactive material.

Do you qualify?

You likely qualify if…

you have been diagnosed with hepatocellular carcinoma (liver cancer) that is at least 5 centimeters in size
your liver function is relatively well-preserved (Child-Pugh class A)
you are in good enough health to tolerate the procedure (ECOG 0 or 1)
your blood work shows acceptable levels of blood cells, liver enzymes, and kidney function
you have a life expectancy of at least 3 months
your tumor does not have certain high-risk features like invasion into major blood vessels or very abnormal vessel patterns

You likely don't qualify if…

you have cancer that has invaded your hepatic vein (a major vein in the liver)
you have main portal vein invasion (cancer in a major blood vessel)
you have a TIPS procedure (a surgically placed shunt between liver blood vessels)
you have significant chronic lung disease such as severe COPD or interstitial lung disease
you have a biliary stent or surgically created connection between your bile duct and intestines

What participation looks like

If you qualify and enroll, you will come to the hospital for a single day of treatment. On that day, the medical team will perform imaging scans to map your tumor's blood supply, calculate the precise radiation dose needed, and then deliver the radioactive microspheres directly to your tumor through a catheter (thin tube). The entire process—planning, imaging, dosing, and treatment—happens in one visit, which means you can go home the same day rather than returning for multiple appointments.

AI-generated summary from trial data · Aug 31, 2026 · Not medical advice

Trial locations(4 sites)

South Korea

National Cancer Center, Goyang

Samsung Medical Center, Seoul

Seoul National University Hospital, Seoul

Severance hospital, Seoul