Recruiting

Single radiation treatment versus five treatments for early-stage breast cancer

Plain-English translation of NCT06946238 on ClinicalTrials.gov ↗ · Source last updated December 2025 · Translation generated August 2026 · How we translate trials

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This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a new way to deliver radiation therapy to early-stage breast cancer patients. Instead of the standard five separate radiation treatments, researchers want to see if giving all the radiation in a single, precisely targeted session works just as well—with fewer trips to the hospital and potentially fewer side effects.

Standard radiation therapy for early breast cancer requires patients to return for treatment five times, which is inconvenient and time-consuming. This trial aims to see whether modern precision radiation technology can safely and effectively deliver the same total dose in just one session, making treatment simpler for patients while maintaining the same cancer-fighting power.

Do you qualify?

You likely qualify if…

you are at least 40 years old
you have been diagnosed with early-stage breast cancer that is 3 centimeters or smaller
your cancer has one of two favorable types: Luminal A or Luminal B HER2-negative
your lymph nodes are cancer-free based on testing
you have no evidence that cancer has spread to other parts of your body
you have had surgery to remove the tumor with clear margins (no cancer cells at the edges)

You likely don't qualify if…

you are younger than 40 years old
you have tumors larger than 3 centimeters
you have cancer in multiple areas of the breast
you have a genetic mutation (BRCA1 or BRCA2) that increases breast cancer risk
you have certain autoimmune or collagen diseases like lupus or rheumatoid arthritis

What participation looks like

If you join this trial, you will be randomly assigned to receive either one large dose of radiation or five smaller doses delivered over one week. Either way, you'll visit the radiation center for planning scans and treatment sessions. The single-dose group would need just one treatment day, while the five-dose group would return five times. The trial will follow you over time to monitor how well the treatment works and check for any side effects.

AI-generated summary from trial data · Aug 15, 2026 · Not medical advice

Trial locations(1 site)

Italy

IRCCS San Raffaele Scientific Institute, Milan