Plain-English translation of NCT06946901 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination approach for pancreatic cancer that has spread to the lining of the abdominal cavity. The study combines two types of chemotherapy: cisplatin HIPEC (a heated chemotherapy solution delivered directly into the abdomen during surgery) plus nab-paclitaxel and gemcitabine (standard chemotherapy given through the vein). Researchers want to learn whether this combination can improve survival and understand how safe the treatment is.
Pancreatic cancer that spreads to the abdominal lining is very difficult to treat with standard chemotherapy alone. This trial explores whether delivering heated chemotherapy directly to where the cancer has spread, combined with systemic chemotherapy, might work better and give patients a better chance of living longer.
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If you join this trial, you will first undergo imaging scans and exploratory surgery to confirm that your cancer has spread to the abdominal lining. During surgery, you'll receive two cycles of the heated chemotherapy. After surgery, you'll receive multiple cycles of standard intravenous chemotherapy over several months. Throughout the trial, you'll have regular imaging scans and blood tests to monitor how you're responding to treatment, and your care team will adjust your treatment plan based on these results and their recommendations.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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