Plain-English translation of NCT06947135 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether —a strong pain reliever—can protect your heart from additional damage when given as an injection around a nerve in your neck before emergency surgery to open a blocked heart artery. Half of the participants will receive , and half will receive a saline (salt water) placebo injection. Researchers believe the medication may reduce injury that occurs when blood flow suddenly returns to the heart muscle.
When a heart attack happens, the blocked artery is starved of oxygen. When doctors reopen the artery during emergency surgery, blood rushes back in—but this sudden return of blood flow can actually cause additional damage to the heart muscle. This trial is exploring whether the medication can protect against this 'reperfusion injury' and improve outcomes for heart attack patients.
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If you join this trial, you will be randomly assigned to receive either a or saline injection around a nerve in your neck—given by ultrasound guidance just before your emergency heart surgery. After the injection, you will proceed with your regular heart artery surgery as planned. The research team will then measure the size of your heart damage using an MRI scan within 7 days or at hospital discharge, whichever comes first. They will also track your heart function, any complications, and your health status for 30 days after the heart attack.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
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