Plain-English translation of NCT06949891 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Acromegaly is caused by a tumor in the pituitary gland at the base of your brain that makes too much growth hormone. This trial is testing whether following a low-carbohydrate ketogenic diet—alongside the medication you're already taking—can help reduce hormone levels, ease symptoms like excessive sweating and joint pain, and improve your quality of life. A small earlier study showed promising results, so researchers want to test this approach more thoroughly in a larger group.
Most people with acromegaly don't fully improve with surgery and current medications alone. This medication helps only about 4 out of 10 patients reach normal hormone levels, and even when hormone levels improve, symptoms and quality of life don't always get better. A low-carbohydrate diet might offer an additional way to reduce hormone levels and help manage the metabolic problems that often come with this disease.
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You'll be randomly assigned to follow either a low-carbohydrate ketogenic diet or a standard healthy Mediterranean diet for 6 months total. If assigned to the ketogenic diet, you'll start with a stricter version (very low carbohydrates) for 3 months, then move to a slightly less strict version for another 3 months. Throughout the study, your doctors will monitor your hormone levels, symptoms, and overall health to see if the diet helps improve your condition.
AI-generated summary from trial data · Jul 12, 2026 · Not medical advice
Netherlands