Recruiting

Tracking brain changes and cognitive health in older adults over 12 years

Plain-English translation of NCT06953167 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

This is a long-term follow-up study for people aged 65 and older who participated in earlier dementia research. Researchers will continue to monitor your cognitive health and use blood tests to measure brain proteins associated with Alzheimer's disease, tracking how these markers change over up to 12 years total. The study aims to understand which people with brain changes go on to develop cognitive problems and which remain stable.

We still don't fully understand why some older adults with signs of Alzheimer's-related brain changes stay cognitively healthy while others experience memory and thinking problems. This long-term study will help identify which people are at higher risk for cognitive decline and which protective factors may keep some people's brains healthier.

Do you qualify?

You likely qualify if…

you are over 65 years old
you previously completed the CHARIOT:PRO screening study between 2015 and 2018
you had either a brain PET scan or spinal fluid test as part of your earlier screening
you have the mental capacity to consent to participate, or have a trusted family member or friend who can advise the researchers on your behalf
you have a reliable study partner (family member, partner, or close friend) willing to be involved in the study

You likely don't qualify if…

you have significant vision or hearing problems that would prevent you from completing cognitive tests
you are unable to commit to study visits and assessments over the follow-up period
you have a history of alcohol or drug dependence within the last 3 years
you have a medical condition or disability that would make study participation unsafe or unable to be completed

What participation looks like

You will attend study visits over at least the next 3 years (extending your total involvement to up to 12 years from your original screening). At each visit, you will complete cognitive tests, physical and neurological exams, and blood draws to measure brain-related proteins. A trusted family member or friend will need to attend your first visit in person and provide information about your everyday functioning, though they can participate remotely in future visits if needed.

AI-generated summary from trial data · Jun 16, 2026 · Not medical advice

Trial locations(1 site)

United Kingdom

Imperial College London, London

View full record on ClinicalTrials.gov