Plain-English translation of NCT06956703 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study invites people with moderate to severe Crohn's disease or ulcerative colitis who are switching to a new biologic medication to participate in understanding how their body responds to treatment. Researchers will collect blood and stool samples, plus small tissue samples during routine endoscopy appointments, at the start of treatment, at 3 months, and at 12 months. The goal is to identify biological markers that might predict which patients will improve with which medications.
Currently, doctors cannot reliably predict which patients will respond well to which biologic medications for inflammatory bowel disease. By studying the blood, stool, and tissue samples from patients starting this medication, researchers hope to find patterns that could help doctors choose the most effective treatment for each individual patient and improve outcomes.
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If you join this study, you'll continue seeing your regular gastroenterologist who will prescribe your biologic medication as normal. At three time points over 12 months—at the start, after 3 months, and after 12 months—you'll provide blood and stool samples. When you have your routine endoscopy appointments (the camera procedure doctors already do to check your bowel), the research team will take a few extra tiny tissue samples during the procedure. Your doctor will track how well the medication is working for you, and researchers will analyze your samples to look for patterns that might explain why the treatment works differently for different people.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United Kingdom
Sponsor
University of Nottingham
Collaborators
Nottingham University Hospitals NHS Trust
Enrollment target
~240 participants
Started
December 2022
Primary completion
February 2027
Age range
16 Years and older
Last updated on clinicaltrials.gov in May 2025.
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Central contact
Gordon Moran Professor
University of Nottingham
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