Plain-English translation of NCT06959147 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether combining two treatments works better than one alone for people with persistent nerve pain after shingles. One group receives a radiofrequency procedure (which uses heat energy to calm overactive nerves), while the other group receives the same procedure plus an injection of liposomal bupivacaine, a long-acting numbing medication that can provide pain relief for up to 72 hours. The study will compare how well each approach reduces pain over six months.
Many people continue to suffer severe pain long after a shingles rash heals, and standard treatments don't work for everyone. Researchers believe that adding the numbing medication might enhance pain relief and reduce the lingering discomfort that sometimes occurs after the procedure alone.
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If you enroll, you will be randomly assigned to one of two groups. Both groups will receive the radiofrequency procedure performed under imaging guidance to target the affected nerve. One group will also receive an injection of the numbing medication two hours after the procedure. You will have assessments before the procedure and then follow-up phone calls at one week, one month, three months, and six months afterward to track how your pain changes. The entire study runs from December 2024 through December 2026.
AI-generated summary from trial data · Sep 3, 2026 · Not medical advice
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