Recruiting

Testing immune cells enhanced to fight advanced melanoma

Plain-English translation of NCT06961357 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated July 2026 · How we translate trials

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Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing a new treatment called CD40L-augmented TIL for patients with advanced melanoma that hasn't responded to standard therapy. TIL stands for tumor-infiltrating lymphocytes—immune cells taken from your own tumor that are grown and enhanced in the laboratory to be better at fighting cancer. The study will give you a single dose of these enhanced cells along with standard supportive care to see if this treatment can help control your melanoma.

Advanced melanoma can be difficult to treat, especially when it stops responding to standard immunotherapy drugs. This medication aims to give your own immune system a more powerful tool by taking your cancer-fighting cells, making them stronger, and putting them back into your body to target the melanoma more effectively.

Do you qualify?

You likely qualify if…

you have been diagnosed with advanced (Stage III or IV) melanoma that cannot be surgically removed, or melanoma that has spread to other parts of your body
your melanoma has stopped responding to, or you were unable to tolerate, at least one standard cancer treatment
you are at least 18 years old (age preference is 18-75, though older patients may be considered)
you have adequate organ and marrow function and are generally in good enough health to tolerate the treatment
you do not have HIV, hepatitis B, or active hepatitis C infection

You likely don't qualify if…

you have received other cancer treatments within the 4 weeks before the study begins
you are unable to have a tumor sample removed for cell preparation
you have active or untreated brain metastases (though treated and stable brain tumors are allowed)
you have significant heart disease or other serious medical conditions that would make this intensive treatment unsafe

What participation looks like

First, doctors will remove a sample of your tumor to grow and enhance your immune cells in the laboratory—this typically takes several weeks. Once the cells are ready, you will receive chemotherapy drugs to prepare your body, followed by an infusion of your enhanced immune cells and a standard immune-boosting medication. You will then be closely monitored with regular clinic visits and tests to check how well the treatment is working and manage any side effects. The study will track your health and cancer response over time to see if this approach helps patients with advanced melanoma.

AI-generated summary from trial data · Jul 4, 2026 · Not medical advice

Trial locations(1 site)

United States

Moffitt Cancer Center, Tampa, Florida