Recruiting

Online versus in-person brain training for multiple sclerosis patients

Plain-English translation of NCT06964581 on ClinicalTrials.gov ↗ · Source last updated May 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether cognitive rehabilitation—a computerized brain-training program designed to help with thinking, memory, and attention problems—works just as well when you do it at home on your own computer as when you do it in person with a therapist present. People with multiple sclerosis often experience cognitive difficulties, and this study wants to find out if remote, at-home training can be an effective and convenient alternative to in-person sessions.

Many people with multiple sclerosis struggle with memory, attention, and thinking skills, which can affect their daily life. This trial exists to see whether at-home, computer-based training could give patients the same benefits as in-person therapy, while offering greater flexibility and convenience.

Do you qualify?

You likely qualify if…

you have been diagnosed with multiple sclerosis (relapsing-remitting, primary progressive, or secondary progressive type) for at least 3 to 6 months
you are between 18 and 65 years old
you have mild to moderate neurological disability (confirmed by your neurologist using a standard disability scale)
you report at least one cognitive problem—such as memory loss, attention difficulties, or trouble with planning and organizing—that a screening test confirms
you have reliable internet access at home and can see and hear well enough to use a computer program

You likely don't qualify if…

you have other neurological conditions besides multiple sclerosis
you have a history of psychiatric disorders
you have a history of alcohol or drug abuse
you have severe vision problems that cannot be corrected with glasses or contacts

What participation looks like

You will be randomly assigned to receive either three hours per week of cognitive training at home using a computer program you work through on your own, or three hours per week of the same training in person with a therapist who guides you through the exercises. The study will measure how well the treatment works for attention, memory, and other thinking skills at the beginning and after the treatment period ends. You'll also complete questionnaires about how the training affects your daily life, energy levels, and overall well-being.

AI-generated summary from trial data · Jun 19, 2026 · Not medical advice

Trial locations(1 site)

Italy

Azienda Ospedaliera Universitaria Integrata Verona - UOC di Neuroriabilitazione, Verona, verona