Plain-English translation of NCT06965062 on ClinicalTrials.gov ↗ ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This is an early-stage study testing a surgical procedure called cervical lymphatico-venous bypass, which creates a connection to help the brain drain toxic proteins more effectively. Researchers believe that buildup of these proteins contributes to Alzheimer's disease, and improving drainage might slow cognitive decline or even improve thinking and memory. The study will carefully monitor your safety and look for signs of improvement using cognitive tests, brain imaging, and blood biomarkers.
Current Alzheimer's medications offer only modest benefits and eventually stop working. Recent research suggests that toxic proteins accumulate in the brain because the natural drainage system isn't working well enough. This procedure offers a potential new approach by directly improving how the brain clears these harmful proteins.
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You would undergo a surgical procedure under general anesthesia to create a bypass connection in your neck, designed to improve brain drainage. Before and after surgery, you will undergo memory and thinking tests, brain imaging scans (MRI and PET), and blood tests to measure biomarkers and assess any changes. The study team will monitor your safety closely and track your cognitive function, daily abilities, and behavior over time to see whether the procedure helps.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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