Plain-English translation of NCT06965335 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are trying to understand why some people develop colorectal cancer much earlier in life than others. This study collects tumor samples and blood from patients with early-onset colorectal cancer (diagnosed before age 40) and compares them to patients diagnosed after age 60. By studying these samples in the laboratory, scientists hope to discover genetic and biological differences that might explain early-onset cases and eventually lead to better prevention and treatment options.
Colorectal cancer in young adults is becoming more common, but doctors don't fully understand why some people get it decades earlier than expected. This research aims to find the biological clues hidden in tumor tissue and blood that could explain early-onset cases and help identify people at higher risk.
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You would allow researchers to use your existing tumor tissue samples (already collected as part of your medical care) and possibly a small blood sample (if available) for laboratory analysis. There are no new procedures or visits required beyond what you've already had for your diagnosis and treatment. Researchers will study your samples in a secure, confidential way to look for biological patterns that might explain why some people develop colorectal cancer early in life.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
Italy
Sponsor
Niguarda Hospital
Enrollment target
~20 participants
Started
April 2024
Primary completion
December 2026
Age range
18 Years – 40 Years
Last updated on clinicaltrials.gov in May 2025.
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Central contact
Salvatore Siena, MD
Niguarda Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.