Plain-English translation of NCT06966336 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how serious burn injuries affect the body's ability to handle heat and exercise. This study will have burn survivors and healthy volunteers exercise in a warm room (heated to about 104°F), then rest, and repeat this cycle three times. The research team will test each person twice — once in dry conditions and once in humid conditions — to see how humidity changes the body's response.
People with large burn injuries often have trouble controlling their body temperature and may struggle during physical activity or in hot environments. This research aims to understand exactly how burn scars and skin grafts affect temperature control, which could help doctors create better exercise programs and safety guidelines for burn survivors.
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You will visit the research facility on two separate occasions. During each visit, you'll enter a heated chamber (kept at about 104°F) where you'll exercise for 30 minutes, rest for up to 20 minutes while remaining in the heat, and repeat this cycle up to three times total. One visit will be in a dry environment, and the other in a humid environment. Researchers will monitor your vital signs and body's response throughout the entire session.
AI-generated summary from trial data · Aug 22, 2026 · Not medical advice
United States
Sponsor
University of Texas Southwestern Medical Center
Collaborators
Texas Health Resources
Enrollment target
~70 participants
Started
August 2025
Primary completion
August 2030
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in September 2026.
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Central contact
Craig Crandall, PhD
University of Texas Southwestern Medical Center
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