Plain-English translation of NCT06967519 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing how two common malaria medications—artemether-lumefantrine and artesunate-amodiaquine—work in children, especially those taking dolutegravir for HIV. The researchers want to understand whether these malaria treatments interact with HIV medication, and whether they affect how well the HIV medication works or how the body changes over time.
Many children in Africa need to treat both HIV and malaria at the same time, but we don't fully understand whether these treatments work safely together or if one malaria medication might be better than another when combined with this HIV medication. This study will help doctors choose the safest and most effective approach.
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You and your family would visit the clinic regularly over two years. When you develop malaria, you would receive one of the two study malaria medications and be monitored to see how well it works and whether it affects your HIV treatment. In the first year, you would always receive the same malaria medication. In the second year, some participants would alternate between the two medications each time they're treated for malaria. The researchers would also take blood samples and measure your weight and body composition to track any changes.
AI-generated summary from trial data · Jul 20, 2026 · Not medical advice
Uganda