Plain-English translation of NCT06968390 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing accelerated intermittent theta burst stimulation (iTBS), a type of transcranial magnetic stimulation (TMS) that uses magnetic pulses to stimulate specific areas of the brain. The treatment has shown promise in helping people with severe depression recover quickly—sometimes in just a few days. This study will see if this newer, faster approach is safe and effective for pregnant people and new mothers with depression.
Perinatal depression—depression during pregnancy and in the first year after birth—affects about one in five people but is often missed and undertreated. Current treatments like antidepressants work slowly, have mixed results, and can make patients anxious about safety. This treatment could offer a faster, medication-free option that might help more pregnant and postpartum people get relief.
You likely qualify if…
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You would receive 10 brain stimulation sessions per day for 5 consecutive days (50 sessions total), delivered through a magnetic coil held against your scalp. Each session takes a few minutes, and sessions are spaced at least 25 minutes apart throughout each day. You would also have psychiatric evaluations and mood assessments before, during, and after treatment, and you would need to keep your mental health provider and obstetrician informed throughout.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States
Sponsor
Brigham and Women's Hospital
Enrollment target
~24 participants
Started
August 2025
Primary completion
November 2026
Age range
18 Years – 55 Years
Sex
Female only
Last updated on clinicaltrials.gov in September 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Interventional Psychiatry Research Group
Brigham and Women's Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.