Plain-English translation of NCT06972056 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Migraine research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether atogepant, propranolol, or topiramate can help prevent migraines in adults. The study will randomly assign participants to take one of these three medications for 12 weeks to see which one helps reduce the number of moderate to severe headache days. Researchers want to understand which medication works best for different people.
While several medications can prevent migraines, doctors don't always know which one will work best for each patient. This trial compares three different treatments head-to-head to help guide future treatment decisions and give patients and doctors better information about their options.
You likely qualify if…
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You'll start by keeping a daily headache diary for four weeks to confirm you qualify. If you do, you'll be randomly assigned to take one of the three medications daily for 12 weeks. You'll have research visits at baseline, and then at weeks 4, 8, 12, 24, and 48 to check how the medication is working. Throughout the first 16 weeks, you'll continue tracking your headaches in a daily diary so researchers can measure whether the medication reduces your moderate to severe headache days by at least half.
AI-generated summary from trial data · Aug 1, 2026 · Not medical advice
United States