Plain-English translation of NCT06974604 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Neoplasms research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a dexamethasone mouthwash can prevent a common and painful side effect—mouth sores—that happens when patients take datopotamab deruxtecan (a new cancer-fighting drug). You would use the medication as a preventive rinse while receiving your cancer treatment. The goal is to help keep your mouth comfortable during therapy.
Datopotamab deruxtecan is an effective cancer drug, but it often causes painful mouth sores that can make eating and talking difficult. This trial wants to find out if using this special mouthwash from the start can stop those sores from developing in the first place.
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You would receive datopotamab deruxtecan as your cancer treatment on a standard schedule, and you would also use the dexamethasone mouthwash regularly (rinsing and swishing as instructed) to help prevent mouth sores. The study involves about 60 participants total, and you would have regular visits with the research team to check your mouth health, manage any side effects, and monitor how well the treatment is working for your cancer. Your participation would continue through your cancer treatment cycles.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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