Recruiting

Testing a new injection treatment for hard-to-control moderate-to-severe asthma

Plain-English translation of NCT06977581 on ClinicalTrials.gov ↗ · Source last updated November 2026 · Translation generated June 2026 · How we translate trials

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Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new medication called to see if it can help people with moderate-to-severe asthma that isn't responding well to their current treatments. Some participants will receive the medication as injections over 12 weeks, while others will receive a placebo (a shot with no medicine in it). Researchers will compare how both groups do to find out if this treatment is safe and effective.

Many people with moderate-to-severe asthma struggle to control their symptoms even when taking their regular maintenance medications. This trial exists to find out whether this new treatment could help these patients breathe easier and improve their quality of life.

Do you qualify?

You likely qualify if…

you are between 18 and 70 years old
you have had moderate-to-severe asthma for at least 12 months that is not well controlled with your current medications
you have had at least one asthma attack in the past 12 months that required oral or injectable steroids for 3 or more days
you have been taking a medium-to-high dose asthma controller medication (inhaled steroid combined with another type of asthma drug) for at least 12 months without changing the dose in the last 3 months
your body mass index is between 18 and 40 kg/m²

You likely don't qualify if…

you have any lung disease besides asthma, such as COPD, cystic fibrosis, emphysema, or pulmonary fibrosis
you have had a serious infection requiring hospitalization or antibiotic treatment within the past 60 days
you are currently taking or have recently taken other biologic asthma medications (such as those targeting IL-4, IL-5, or IgE) or JAK inhibitors
you have taken systemic steroid pills or injections within the past 28 days
you have active suicidal thoughts or a recent history of suicidal behavior

What participation looks like

You would visit the study clinic 9 times over about 7.5 months. During the first 12 weeks, you would receive injections of either the new medication or a placebo. You would not know which one you're getting — that's part of the study design. The research team will track how well you're breathing, how often you have asthma attacks, and any side effects you experience throughout the study period.

AI-generated summary from trial data · Jun 26, 2026 · Not medical advice

Testing a new injection treatment for hard-to-control moderate-to-severe asthma

What is this trial?

Do you qualify?

What participation looks like

Trial locations(137 sites)