Plain-English translation of NCT06979323 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Asthma research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
The IMAGINE Study is testing a medication called to see how it affects the airways and lungs in people with asthma that is hard to control, even with strong steroid inhalers. This treatment is a monoclonal antibody — a type of protein that targets specific immune cells involved in asthma. Researchers want to understand whether the medication can actually reshape and improve how the lungs work in people whose asthma is driven by high numbers of eosinophils (white blood cells that cause inflammation).
Many people with asthma struggle to control their symptoms even when taking the strongest available inhaler medications, and their airways become permanently narrowed and damaged over time. This trial exists to see whether the medication can reduce that underlying damage and help airways function better — not just by treating symptoms, but by actually healing the lung structure itself.
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You would receive injections of the medication over the course of the study at clinic visits. Some participants may also be asked to undergo a bronchoscopy — a procedure where doctors use a thin, flexible tube to look inside your airways and collect tiny tissue samples to study under a microscope — to help researchers see exactly how the treatment is affecting your lungs. Throughout the study, you will have breathing tests, blood tests, and imaging scans to measure changes in your lung function and structure.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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