Testing a new combination treatment for lung pressure caused by chest scarring

This trial is testing whether rituximab lymph node injection combined with a lung vessel procedure works better than the procedure alone for treating a condition called fibrosing mediastinitis that causes high lung pressure. Fibrosing mediastinitis happens when scar tissue builds up in the center of your chest and squeezes your lung blood vessels, making it hard to breathe. The study compares two groups: one receives both the procedure and the medication, and one receives just the procedure.

High lung pressure from chest scarring is hard to treat and can seriously limit what patients can do. Doctors want to know if adding this medication to the standard procedure might help more patients feel better and breathe easier.