Plain-English translation of NCT06986265 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is investigating why many people with advanced kidney failure experience muscle loss and weakness — a condition called cachexia — and how their gut bacteria and body's inflammatory response may play a role. Researchers will collect blood and stool samples from dialysis patients, measure muscle and body composition, and track these changes over time to understand the connections between gut health, inflammation, and muscle wasting in kidney disease.
Muscle loss and weakness are serious complications that affect many dialysis patients and can lead to worse health outcomes and increased mortality. However, doctors don't fully understand why this happens or how the gut bacteria and toxic substances that build up in kidney failure contribute to this problem. This study aims to fill that gap and potentially identify new ways to prevent or treat muscle loss.
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If you join this study, you will visit the research center for assessments of your body composition and muscle strength. You will provide blood samples and stool samples so researchers can study your gut bacteria, inflammation markers, and kidney toxins. You will also have your muscle tissue examined (through a biopsy or scan) and your dialysis treatment details reviewed. The study will follow you over time with repeated visits to monitor how these measurements change, allowing researchers to track the connections between your gut health and muscle loss.
AI-generated summary from trial data · Jul 20, 2026 · Not medical advice
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