Recruiting

Testing a new treatment to help recovery after stroke

Plain-English translation of NCT06990867 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing whether a new medication called can help people recover better after an ischemic stroke (when blood flow to the brain is blocked). The study will compare to a placebo (an inactive pill) in about 740 people who arrive for care between 4.5 and 24 hours after their stroke symptoms start. Researchers want to see if this treatment can improve how well people function after a stroke and whether it is safe.

Most stroke treatments work best when given very early—within the first few hours. This medication is being tested to see if it can still help people who come to the hospital later, when they've missed the window for standard treatments. If successful, this treatment could offer hope to many more stroke patients.

Do you qualify?

You likely qualify if…

you are between 18 and 90 years old
you have had an acute ischemic stroke confirmed by imaging, with a blood clot blocking a major artery in your brain
you arrive for medical care between 4.5 and 24 hours after your stroke symptoms began
imaging shows that part of your brain tissue can still potentially be saved
your stroke severity is moderate or worse (NIHSS score of 5 or higher)

You likely don't qualify if…

you have signs of a very large stroke or brain swelling on imaging
you have any active bleeding or a history of bleeding disorders that puts you at high risk
your blood pressure is severely high (systolic ≥ 185 or diastolic ≥ 110) and cannot be controlled with medication
your blood glucose (blood sugar) is extremely high (>400) or dangerously low (<50) and cannot be quickly corrected
you have had major trauma, surgery, or invasive procedures recently

What participation looks like

If you qualify, you will be randomly assigned to receive either or a placebo (fake medication). The study has two parts: in Part 1, researchers test different doses to find the best one; in Part 2, all participants receive either the best dose or placebo. You will have regular medical visits and tests to monitor your recovery, check for any side effects, and measure how well the medication is working using standard stroke recovery assessments.

AI-generated summary from trial data · Jun 7, 2026 · Not medical advice

Trial locations(83 sites)

United States

Corxel Investigational Site, Long Beach, California

Corxel Investigational Site, Sacramento, California

Corxel Investigational Site, Colorado Springs, Colorado

Corxel Investigational Site, Washington D.C., District of Columbia

Corxel Investigational Site, Delray Beach, Florida