Plain-English translation of NCT06993597 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are testing a new imaging method called Brillouin microscopy that measures how stiff your cornea (the clear front part of your eye) is. They want to see whether corneal stiffness can help doctors understand who is at risk for glaucoma and how well treatment is working. If successful, this imaging technique could become a new tool for glaucoma care.
Glaucoma damages the optic nerve and can cause vision loss, but doctors currently lack simple ways to predict who will develop the disease or how quickly it will progress. This study explores whether measuring corneal stiffness could become a new biomarker—a measurable sign—to improve glaucoma diagnosis and monitoring.
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If you qualify, you'll come in for imaging visits where researchers will use the Brillouin microscopy device to scan your cornea—a quick, painless, non-contact procedure. If you're newly diagnosed with glaucoma and receive eye drop treatment, you'll have additional imaging visits at 3 and 6 weeks to track how the medication affects your corneal properties. Healthy control participants will have a single baseline imaging visit for comparison.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
United States
Sponsor
University of Maryland, Baltimore
Collaborators
National Eye Institute (NEI)
Enrollment target
~60 participants
Started
September 2025
Primary completion
March 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in September 2025.
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Central contact
Osamah Saeedi, MD
University of Maryland, Baltimore
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