Reducing Nasal Medications in Cystic Fibrosis Patients on New Therapy

This trial is testing whether people with cystic fibrosis who are doing well on newer, highly effective modulator therapy can safely reduce or stop the nasal treatments they use daily—like saline rinses, steroid sprays, and nasal antibiotics. The study will compare two groups: one that continues their current nasal medications and one that stops them. By tracking symptoms, nasal health, and inflammation markers, researchers hope to learn whether these nasal treatments are still necessary for patients whose lung disease is already well-controlled.

New cystic fibrosis medications have dramatically improved how patients feel and breathe, which raises an important question: do patients still need all their daily nasal treatments? This study exists to figure out which nasal medications can safely be stopped, so patients can simplify their routines, reduce costs, and avoid unnecessary medication side effects.