Plain-English translation of NCT06997965 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Crohn Disease research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing a medication called to see if it can help treat a common complication of Crohn's disease called strictures—areas where the intestine becomes narrowed and inflamed, causing pain and difficulty eating. About 60 people with Crohn's disease and bowel strictures will receive this medication over 24 weeks to see if it safely reduces inflammation and improves symptoms.
Strictures in Crohn's disease are a stubborn problem that often leads to surgery or other invasive procedures. Researchers want to know if this medication can shrink the inflammation causing the narrowing, potentially helping patients avoid surgery and eat more normally.
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Over 24 weeks, you will visit a study clinic about 8 times. At the start, you'll have a 5-week screening period with imaging and a colonoscopy to confirm your stricture. Then you'll receive the medication: three intravenous infusions at weeks 0, 4, and 8, followed by four subcutaneous injections (shots under the skin) at weeks 12, 16, 20, and 24. Throughout the study, you'll have blood tests, stool samples collected, complete daily symptom diaries, and undergo repeat imaging and colonoscopy at the end to see if the medication reduced inflammation.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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