Plain-English translation of NCT06999434 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers are testing a new imaging agent called [18F]3F4AP to see how well it can detect nerve damage in the brain and spinal cord. This agent is used with PET scanning, a type of medical imaging that shows how tissues are working. The study wants to understand how this new imaging tool moves through the body and whether it can help doctors better diagnose conditions like Alzheimer's disease, multiple sclerosis, and spinal cord injury.
Currently, doctors have limited ways to directly visualize nerve damage in living patients. This study aims to develop a better imaging tool that could help detect nerve damage earlier and more accurately, potentially leading to better diagnosis and treatment for people with brain and spinal cord conditions.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will visit the research center for up to three PET scanning sessions over time. During each visit, you'll receive an injection of the imaging agent and then lie still in a scanner for imaging. The study team will monitor how the agent moves through your body and how well it detects nerve damage. Your participation helps researchers understand whether this new imaging tool could become useful for diagnosing nerve and brain conditions in the future.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Yale University
Collaborators
National Institute for Biomedical Imaging and Bioengineering (NIBIB), National Institute on Aging (NIA)
Enrollment target
~105 participants
Started
May 2025
Primary completion
May 2030
Age range
18 Years – 90 Years
Last updated on clinicaltrials.gov in May 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Shannan Henry
Yale University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.