Plain-English translation of NCT07000253 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing the best timing for combining with surgery in people who have esophageal or stomach cancer that has spread to only a few places in the body. All participants first receive 4 months of plus and/or targeted therapy (depending on tumor markers). Then, if their cancer hasn't gotten worse, they are randomly assigned to either continue this treatment for 4 more months before surgery, or go straight to surgery right away.
About 25% of people with advanced stomach or esophageal cancer have cancer that spreads to only a few sites, and early studies suggest that combining surgery with may help them live longer. However, doctors don't yet know whether patients do better if they receive for a longer time before surgery, or if they should have surgery sooner.
You likely qualify if…
You likely don't qualify if…
You will start with 4 months of combined with and/or targeted therapy. After imaging tests check your response, you'll be randomly assigned to one of two groups: either continue this medication for 4 more months before having surgery, or proceed directly to surgery followed by 4 months of additional treatment. Throughout the study (lasting about 4–5 years total), you'll have regular CT scans, blood tests to check for circulating tumor cells, and quality-of-life questionnaires to track how you're doing.
AI-generated summary from trial data · Sep 4, 2026 · Not medical advice
Netherlands
Norway
Spain
Age range
18 Years and older
Last updated on clinicaltrials.gov in September 2026.
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Central contact
Hanneke van Laarhoven, MD, PhD, PhD
Amsterdam UMC
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