Plain-English translation of NCT07000708 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a simple eating pattern called time-restricted eating (TRE)—where you eat only during an 8-hour window each day—can help strengthen your immune system's response to vaccines. As we age, our immune cells become less efficient at fighting infections, which means vaccines don't work as well. Researchers believe that by giving your body a longer fasting period each day, you may be able to restore some of that lost immune power and get better protection from flu and COVID-19 vaccines.
Older adults often don't respond as well to vaccines because aging weakens the immune system's ability to clean up and refresh its cells. This study is testing whether this eating pattern could be a simple, cost-free way to rejuvenate immunity and help older people get better protection from serious infections.
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You will be randomly assigned to either follow your normal eating habits or try time-restricted eating (eating only between 8 AM and 4 PM, for example) for four weeks. During this time, researchers will take blood samples and measure things like body composition, blood pressure, and how your cells work. After four weeks, you'll receive your scheduled flu and COVID-19 vaccinations at your doctor's office, and then return for two follow-up visits—one at 2 weeks and another at 12–14 weeks after vaccination—to see how well your immune system responded to the vaccines.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Germany
Sponsor
Charite University, Berlin, Germany
Collaborators
Max Delbrück Center for Molecular Medicine (MDC), Berlin, Labor Berlin, Germany
Enrollment target
~24 participants
Started
September 2025
Primary completion
September 2026
Age range
60 Years – 85 Years
Last updated on clinicaltrials.gov in September 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Sebastian Hofer, Dr. rer. nat.
Clinical Research Unit, Experimental and Clinical Research Center, Charité, Berlin, Germany & Max-Delbrück Center for Molecular Medicine, Berlin, Germany
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.