Plain-English translation of NCT07000747 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand why dengue fever can become more severe in people with sickle cell disease. This study will collect blood samples from young people with sickle cell disease (both SS and SC types) and compare them to people without sickle cell disease. By studying how their immune cells react to dengue virus in the lab, scientists hope to discover why some people get sicker than others.
Dengue is a virus spread by mosquitoes that causes fever and can become life-threatening. People with sickle cell disease seem to have worse outcomes when they get dengue, but doctors don't fully understand why. This research aims to find those answers so treatments can be improved in the future.
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You would visit the sickle cell center at Guadeloupe University Hospital to donate a blood sample. Researchers will use your blood to study how your immune cells respond to dengue virus in a laboratory setting. The study also involves allowing researchers to compare your blood profile with how effectively mosquitoes can transmit dengue—all done in the lab, not with live mosquitoes.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Guadeloupe