Testing an herbal extract to improve blood flow after stroke

Plain-English translation of NCT07003386 on ClinicalTrials.gov ↗ · Source last updated September 2025 · Translation generated July 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing , a natural compound extracted from Lycoris aurea (a traditional Chinese medicinal herb), to see if it helps people recover better after an acute ischemic stroke. Researchers believe this medication may help restore blood flow to the brain and reduce inflammation. You would receive the medication in addition to the standard emergency stroke care you would normally get.

Even after doctors successfully clear the blood clot causing a stroke, many patients still have poor long-term outcomes because the tiny blood vessels in the brain don't recover properly. This medication is believed to help improve blood flow in these small vessels and protect brain tissue, which could lead to better recovery.

Do you qualify?

You likely qualify if…

you are between 18 and 85 years old
you have been diagnosed with an acute ischemic stroke (caused by a blood clot) within the past 72 hours
you have a stroke severity score of 4–25 on a standard medical scale
this is your first stroke, or you have not had severe lasting problems from a previous stroke
you are willing to sign an informed consent form and participate in all study activities

You likely don't qualify if…

you have a brain tumor, infection, or bleeding in the brain instead of a blood clot
you have severe liver or kidney disease
you are currently taking or have taken other similar medications (cholinesterase inhibitors) in the past 3 months
you have conditions like epilepsy, asthma, severe heart problems, narrow-angle glaucoma, or severe intestinal blockage
you are pregnant, breastfeeding, or have a cardiac pacemaker or other implants that would make MRI scans unsafe

What participation looks like

You would receive plus standard stroke treatment, or standard stroke treatment alone (decided by random assignment). The study will assess your recovery through standard stroke outcome measures, blood tests to check inflammation levels, brain imaging to measure blood flow, and evaluations of your cognitive function. You would be followed to evaluate how well the medication helps your recovery compared to standard treatment alone.

Testing an herbal extract to improve blood flow after stroke

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)