Plain-English translation of NCT07007143 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
After a catheter-based heart valve repair procedure (called transcatheter edge-to-edge repair), doctors need to prevent blood clots, but there's no clear guidance on which blood thinner approach works best. This trial compares two strategies: taking Aspirin alone versus taking Aspirin plus Clopidogrel together for a short period. The goal is to find the safest and most effective approach for patients who don't already need blood thinners for other reasons.
Over 250,000 patients worldwide have had this type of minimally invasive valve repair, but doctors don't yet know the best way to prevent blood clots afterward. Current practice varies widely because no major study has directly compared these blood thinner strategies in this specific patient group.
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You will be randomly assigned to take either Aspirin alone (100 mg daily for at least 12 months) or Aspirin plus Clopidogrel together (Clopidogrel for 3 months, then Aspirin alone). You will have regular follow-up visits to check how well the treatment is working and monitor for any side effects. The study involves at least 12 months of treatment and follow-up care at participating hospitals.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
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