Plain-English translation of NCT07009223 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study investigates whether simple lifestyle changes—regular physical activity, cognitive training, and a Mediterranean-style diet—can help prevent memory and thinking problems in people aged 50 to 80 who have depression or depressive symptoms. The researchers want to understand how exercise, mental exercises, and diet affect your brain health, gut bacteria, and inflammation in the body. By comparing different groups, they hope to identify which lifestyle approaches work best at protecting memory and improving mood.
Depression can sometimes lead to memory problems and cognitive decline, especially as people age. This trial exists to find out whether lifestyle changes—instead of or alongside medication—might prevent these cognitive issues and help people feel better mentally.
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Over 12 weeks, you will be assigned to one of three groups: a control group receiving standard care plus nutrition education, a group that also does supervised exercise with a trainer, or a group that also participates in weekly cognitive training sessions at the hospital. All participants will attend online sessions about healthy eating based on the Mediterranean diet, provide blood and stool samples, and complete memory and thinking tests plus questionnaires at the start, after 12 weeks, and again 3 months later.
AI-generated summary from trial data · Aug 12, 2026 · Not medical advice
Italy