Testing a device to relieve chest pain when arteries are not blocked

Plain-English translation of NCT07010029 on ClinicalTrials.gov ↗ · Source last updated June 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study is testing a device called a coronary sinus reducer in patients who experience chest pain (angina) even though their coronary arteries are not significantly blocked. The device works by narrowing a vein in the heart to improve blood flow to the heart muscle. Researchers want to see if this treatment can reduce chest pain and improve quality of life in people whose symptoms have not improved with medication alone.

Many patients with chest pain have normal or nearly normal coronary arteries, but their symptoms are caused by poor blood flow at the microscopic level in the heart muscle. Current medications don't work well for everyone, so doctors are exploring this device as a new way to help these patients feel better and reduce their risk of future heart problems.

Do you qualify?

You likely qualify if…

you have stable chest pain without significant blockages in your coronary arteries (less than 50% narrowing, or 50–70% narrowing with good blood flow)
you have been diagnosed with coronary microvascular dysfunction confirmed by heart imaging tests
you have already tried maximum doses of chest pain medications for at least three months without adequate relief
you are willing to have a device implanted in your heart through a minimally invasive procedure

You likely don't qualify if…

you have vasospastic angina (a specific type of chest pain caused by artery spasms)
you have had a recent heart attack or acute coronary syndrome within the last 6 months
you have a heart ejection fraction of 30% or lower (very weak heart pumping function)
you have had a pacemaker or defibrillator leads placed in the right side of your heart
you were hospitalized for acute heart failure within the last 3 months

What participation looks like

If you qualify and enroll, you will undergo implantation of the coronary sinus reducer device in a procedure similar to cardiac catheterization. After the device is placed, you will have follow-up visits where doctors will monitor your symptoms, chest pain levels, quality of life, and heart function using imaging tests. The study will track how well the device works and whether it helps relieve your chest pain and improve your heart's pumping function over time.

AI-generated summary from trial data · Jun 5, 2026 · Not medical advice

Trial locations(1 site)

Poland

Medical University of Warsaw, Warsaw

View full record on ClinicalTrials.gov