Plain-English translation of NCT07014917 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination of two medications called and in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have never been treated before. The study compares two different schedules: one group will take for 7 days per cycle, while the other will take it continuously for 28 days per cycle. Both groups will also take throughout the study to see which schedule works better and causes fewer side effects.
Currently, doctors use continuous dosing with these medications, but researchers want to know if giving the medication in shorter bursts (intermittent dosing) might be just as effective while potentially reducing side effects and making treatment easier for patients to tolerate long-term.
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You will be randomly assigned to one of two groups. One group takes for 7 days during each 28-day cycle while taking daily throughout. The other group takes every day for all 28 days of each cycle plus daily . You will have regular visits with the study team for blood tests, physical exams, and check-ins to monitor how well the medication is working and watch for side effects. The study will track your response to treatment over 12 cycles (about one year).
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
Zulfa Omer
Enrollment target
~62 participants
Started
December 2025
Primary completion
June 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
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Central contact
UCCC Clinical Trials Office
University of Cincinnati
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