New immune cell therapy for lupus that hasn't responded to standard treatments

This trial is testing a new treatment called CC-97540 (also called Zola-cel) for people with systemic lupus erythematosus (SLE) or lupus nephritis whose disease remains active despite taking standard lupus medications. The treatment works by using special immune cells called CAR T cells that have been engineered to help control the disease. Researchers want to see if this medication can help people whose lupus has not responded well enough to current treatments.

Many people with lupus continue to have active disease even when taking multiple standard immunosuppressant medications, which can lead to serious organ damage. This trial exists to see whether this new treatment approach can help patients who have run out of good options with conventional drugs.