Plain-English translation of NCT07019857 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The THYMIC study is investigating how much damage is done to a baby's immune system when the thymus gland is removed during heart surgery. Surgeons often remove the entire thymus to get better access to the heart, but this gland is very important for building a strong immune system in infants. This research will compare babies who had their entire thymus removed, babies who had only part removed, and babies who kept their thymus intact—checking their immune health at 12 months after surgery.
Early removal of the entire thymus may weaken babies' immune systems and make them more prone to infections as they grow. Doctors want to know if removing only part of the thymus—when it's possible—could protect the immune system while still giving surgeons the access they need to fix the heart.
You likely qualify if…
You likely don't qualify if…
Your baby will have the heart surgery they need at Nantes University Hospital, where the surgeon will decide during the operation whether to remove all or part of the thymus based on what's safest. After surgery, you and your baby will return for scheduled visits at 12 months, where doctors will do blood tests and other immune system checks to see how well your baby's immunity is developing. The main study visit happens at one year after surgery, and the research team will compare your baby's immune function to other babies in the study.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
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